Lufenuron, the other active ingredient, SENTINEL Flavor Tabs, is an insect development inhibitor which breaks the flea life cycle by inhibiting egg development. Milbemycin oxime eliminates the tissue stage of heartworm larvae and the adult stage of hookworm ( Ancylostoma caninum), roundworm ( Toxocara canis and Toxascaris leonine) and whipworm ( Trichuris vulpis) infestations when administered orally according to the recommended dosage schedule. Milbemycin oxime, one active ingredient in SENTINEL Flavor Tabs, is a macrocyclic anthelmintic which is believed to act by interfering with invertebrate neurotransmission.